Ayahuasca - Who does best
Speaking in general (Ayahuasca is very individual specific) from my observation of hundreds, if not thousands of ceremonies in the USA, I have found that above all else, people who can accept what is being given and allow the journey to develop without resistance does the best.
This is why on your first journey we find it best to focus on relaxing rather than intention. The reason behind this is, early on your intention can become resistance in an instant. Mother Aya gives you what you need, not what you want, and like any relationship, it is best done from a relaxed state. As you become seasoned, you can work with intention.
Of course there are exceptions to this very general rule.